Table 2. Univariate analyses of variables which affect survival in patients with Hodgkin lymphoma (HL) who developed non-small cell lung cancer (NSCLC).

	Localized NSCLC	Regional NSCLC	Distant NSCLC
	P value	P value	P value
Univariate analysis
Age at HL diagnosis (older) §	0.012 *	0.48	0.99
HL stage †	0.62-0.84	0.11-0.16 *	0.63-0.78
HL subtype (mixed cellularity: no) ‡	0.035 *	0.94	0.95
Radiation for HL (radiation: yes)	0.86	0.068 *	0.29
Latency of NSCLC §	0.91	0.89	0.43
Age at NSCLC diagnosis (older) §	0.006 *	0.38	0.59
Calendar year of NSCLC diagnosis (earlier) §	0.098 *	0.25	0.15 *
Radiation for NSCLC (radiation: yes)	0.004 *	0.45	0.54
NSCLC histology ¤	0.63	0.86	0.29
NSCLC grade	0.76	0.42	0.21
Sociodemographic status §	0.54	0.71	0.72
Race (non-white)	0.32	0.036 *	0.61
Gender	0.96	0.81	0.92

*P value <0.2 in univariate analysis. Variables associated with more adverse survival are shown in italics; ^†The range of P-values reflects analyses accounting for 2 possible HL stage assignments in 13 (7%) of the 187 HL-NSCLC patients (see text). No HL stage group was consistently adverse or favorable among the separate analyses. Consequently, HL stage was omitted from Cox proportional hazards multivariate analyses for regional stage NSCLC. Notably, the inclusion of HL stage did not appreciably change the HR or P values of the other variables in the Cox model; ^‡Mixed cellularity subtype versus all others; ^§Variables analyzed with a Cox model, using the single variable of interest; all others were analyzed using the log-rank method; ^¤Grouped into adenocarcinoma (including bronchiolo-alveolar) versus squamous cell carcinoma.