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K562 cells were either left untreated (CTL) or treated with either 1 μM SAHA (a) or 1 μM MS-275 (b). Arrows show examples of modified histone peptides whose abundance is significantly affected by HDACi. Tandem MS sequencing of an N-terminal histone H3 peptide (c), and an N-terminal histone H4 peptide (d), revealed acetylation sites that increased in abundance in response to HDACi treatment.
