Fig 4.

In vivo investigation of the role of R1 and R2 in the transcriptional mechanism of VraR. The bioluminescence signals obtained from S. aureus strains in the presence of 10 μg/ml oxacillin are depicted. Each strain is represented by the name of the promoter fused upstream of the lux operon in the pXEN1 plasmid. Standard deviations were calculated from three independent experiments. The viability experiments showed that the effect of oxacillin on the bacterial growth (number of CFU) was the same for all examined strains (data not shown). RLU, relative light units.