Table 2.
MIC ranges and geometric means (GMs) for genera and species inferred from the phylogramsa
| Name (no. of strains) | MIC range (GM) (μg/ml) for: |
|||||||
|---|---|---|---|---|---|---|---|---|
| 5-FC | MCF | CAS | TBF | VCZ | ITZ | PCZ | AMB | |
| Mucor (12) | >64 (>64) | >4 (>4) | >4 (>4) | 0.125–32 (2.69) | 1–>8 (>6.0) | 0.25–4 (1.19) | 0.125–2 (0.79) | 0.25–0.5 (0.37) |
| Mucor circinelloides sensu lato (8) | >64 (>64) | >4 (>4) | >4 (>4) | 2–32 (8) | >8 (>8) | 1–4 (1.68) | 0.5–2 (1) | 0.25–0.5 (0.32) |
| Mucor racemosus (1) | >64 | >4 | >4 | 0.125 | 2 | 0.25 | 0.125 | 0.5 |
| Mucor hiemalis (1) | >64 | >4 | >4 | 0.25 | 1 | 0.5 | 0.5 | 0.5 |
| Mucor irregularis (1) | >64 | >4 | >4 | 0.5 | >8 | 1 | 1 | 0.5 |
| Mucor indicus (1) | >64 | >4 | >4 | 0.5 | >8 | 1 | 1 | 0.5 |
| Rhizopus (19) | >64 (>64) | >4 (>4) | >4 (>4) | 0.06–32 (3.84) | 4–>8 (>5.5) | 0.125–4 (0.58) | 0.03–2 (0.33) | 0.5–2 (1) |
| Rhizopus arrhizus (14) | >64 (>64) | >4 (>4) | >4 (>4) | 1–32 (21.11) | 4–>8 (>5.9) | 0.125–1 (0.5) | 0.03–0.5 (0.28) | 0.5–2 (0.95) |
| Rhizopus microsporus (5) | >64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.25 (0.12) | 4–8 (4.6) | 0.5–4 (0.87) | 0.25–2 (0.57) | 1–2 (1.15) |
| Syncephalastrum (6) | ≥64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.25 (0.18) | 1–>8 (>5.6) | 0.03–0.5 (0.28) | 0.06–1 (0.31) | 0.03–0.25 (0.09) |
| Syncephalastrum “racemosum” species II (2) | ≥64 | >4 | >4 | 0.25 | ≥8 | 0.5 | 0.25–5 | 0.03–0.06 |
| Syncephalastrum “racemosum” species I (4) | ≥64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.25 (0.15) | 1–>8 (>4.7) | 0.03–0.5 (0.21) | 0.06–1 (0.29) | 0.06–0.25 (0.12) |
| Rhizomucor (8) | >64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.25 (0.11) | 2–>8 (>3.1) | 0.06–0.25 (0.21) | 0.125–0.5 (0.21) | 0.5 (0.5) |
| Rhizomucor pusillus (7) | >64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.125 (0.1) | 2–>8 (>3.0) | 0.25 (0.25) | 0.125–0.5 (0.23) | 0.5 (0.5) |
| Rhizomucor miehei (1) | >64 | >4 | >4 | 0.25 | 4 | 0.06 | 0.125 | 0.5 |
| Lichtheimia (13) | >64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.5 (0.18) | 2–>8 (>5.8) | 0.03–0.5 (0.18) | 0.06–0.25 (0.13) | 0.06–0.5 (0.24) |
| Lichtheimia corymbifera (6) | >64 (>64) | >4 (>4) | >4 (>4) | 0.06–0.25 (0.12) | ≥8 (>8) | 0.06–0.5 (0.22) | 0.06–0.25 (0.20) | 0.25–0.5 (0.31) |
| Lichtheimia ramosa (5) | >64 (>64) | >4 (>4) | >4 (>4) | 0.125–0.5 (0.25) | 2–>8 (>4.6) | 0.03–0.5 (0.19) | 0.06–0.25 (0.11) | 0.06–0.25 (0.12) |
| Lichtheimia ornata (2) | >64 | >4 | >4 | 0.25 | 2–>8 | 0.06–0.125 | 0.06 | 0.25 |
| Cunninghamella (8) | 32–>64 (>58.7) | 0.5–>4 (>2.59) | ≥4 (>4) | 0.06–0.25 (0.09) | >8 (>8) | 1–>64 (>19.0) | 0.5–1 (0.71) | 1–2 (1.54) |
| Cunninghamella bertholletiae (5) | 32–>64 (>55.7) | 1–>4 (>3.03) | ≥4 (>4) | 0.06–0.25 (0.08) | >8 (>8) | 16–>64 (>27.9) | 0.5–1 (0.66) | 1–2 (1.52) |
| Cunninghamella echinulata (3) | >64 | 0.5–>4 | ≥4 | 0.06–0.3 | >8 | 1–>64 | 0.5–1 | 1–2 |
| All isolates (66) | 32–>64 (>63.3) | 0.5–>4 (>3.8) | ≥4 (>4) | 0.06–32 (0.62) | 1–>8 (>5.5) | 0.03–>64 (>0.66) | 0.03–2 (0.33) | 0.03–2 (0.48) |
a
MIC ranges (GMs) for 5-fluorocytosine (5-FC), micafungin (MCF), caspofungin (CAS), terbinafine (TBF), voriconazole (VCZ), itraconazole (ITZ), posaconazole (PCZ), and amphotericin B (AMB). Genera are placed in line with the phylogenetic tree of Fig. 1 except for Rhizomucor. Within the genera, species are arranged according to their position in the trees of Fig. 2.