Table 1.

Comparison of HC2, cobas, and LA for detection of high-risk HPV genotypes^a

Group and comparison	No. of samples	Result of comparison								P valuec	% agreement	Kappa	95% confidence interval
		Neg/neg		Pos/neg		Neg/pos		Pos/pos
		No.	%	No.	%	No.	%	No.	%
Total	1,852
HC2 vs. cobas	1,824	665	35.9	112	6.1	164	9.0	893	49.0	0.002	85.9	0.692	0.659–0.726
HC2 vs. LA	1,849	653	35.3	121	6.5	178	9.6	897	48.5	0.001	83.8	0.671	0.637–0.705
LA vs. cobas	1,824	681	37.3	86	4.7	78	4.3	979	53.7	0.532	91.0	0.815	0.788–0.842
ASC-USb or worse cytology	639
HC2 vs. cobas	626	57	9.1	48	7.7	20	3.2	501	80.0	0.001	89.1	0.565	0.473–0.656
HC2 vs. LA	637	56	8.8	49	7.7	22	3.5	510	80.1	0.001	88.9	0.549	0.456–0.641
LA vs. cobas	626	84	13.4	21	3.4	17	2.7	504	80.5	0.516	93.9	0.779	0.712–0.846
Normal cytology	1,205
HC2 vs. cobas	1,190	594	49.9	63	5.3	144	12.1	389	32.7	<0.001	82.6	0.643	0.600–0.687
HC2 vs. LA	1,204	594	49.3	71	5.9	155	12.9	384	31.9	<0.001	81.2	0.615	0.570–0.660
LA vs. cobas	1,190	593	49.8	64	5.4	61	5.1	472	39.7	0.788	89.5	0.788	0.753–0.823

^aSamples were evaluated for the presence of 1 or more among 14 HPV genotypes (HPV16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, and -68, as well as HPV66) among specimens taken at 1-year follow-up visit after a previous HC2-positive test result, stratified by cytologic result. Of 1,852 1-year follow-up specimens, cobas, LA, and cytology results were missing for 28, 3, and 8 samples, respectively.

^bAtypical squamous cells of undetermined significance.

^cExact McNemar's test.