TABLE 3.
Univariate and multivariate Cox regression model analysis of clinical and demographic factors associated with postdiagnosis death hazards*
| Hazard Ratio |
||
|---|---|---|
| Variable | Unadjusted (95% CI) |
Adjusted (95% CI) |
| histologically confirmed diagnosis | ||
| age category (yrs) | ||
| <20 | 0.06 (0.01–0.46) | 0.05 (0.01–0.39) |
| 20–39 | 0.04 (0.02–0.07) | 0.04 (0.02–0.08) |
| 40–59 | 0.07 (0.06–0.10) | 0.08 (0.06–0.11) |
| 60–79 | 0.22 (0.17–0.28) | 0.23 (0.18–0.30) |
| ≥80 | reference | reference |
| sex | ||
| male | 1.50 (1.21–1.83) | 1.50 (1.20–1.85) |
| female | reference | reference |
| race | ||
| white | reference | |
| black | 1.31 (0.97–1.77) | NS |
| other | 0.80 (0.55–1.17) | NS |
| marital status | ||
| single | reference | reference |
| married | 0.92 (0.68–1.23) | 0.76 (0.56–1.03) |
| divorced/widowed/ separated |
2.20 (1.61–3.01) | 1.13 (0.81–1.57) |
| unknown | 1.86 (1.18–3.02) | 1.26 (0.78–2.03) |
| year of diagnosis | ||
| 2004 | 1.45 (1.03–2.03) | 1.49 (1.06–2.09) |
| 2005 | 0.99 (0.70–1.42) | 1.05 (0.74–1.50) |
| 2006 | 1.02 (0.71–1.46) | 1.03 (0.72–1.48) |
| 2007 | reference | reference |
| size of tumor (quartile) | ||
| <17 mm | reference | reference |
| 18–27 mm | 0.75 (0.41–1.37) | 0.71 (0.39–1.30) |
| 28–41 mm | 1.32 (0.79–2.21) | 1.03 (0.61–1.73) |
| ≥42 mm | 1.72 (1.05–2.83) | 1.29 (0.78–2.14) |
| unknown | 1.67 (1.02–2.73) | 1.37 (0.83–2.25) |
| side of tumor | ||
| midline | reference | reference |
| left | 0.52 (0.38–0.69) | 0.48 (0.36–0.66) |
| right | 0.47 (0.35–0.64) | 0.45 (0.33–0.60) |
| bilateral | 1.37 (0.86–2.18) | 1.28 (0.80–2.06) |
| unknown | 0.32 (0.08–1.31) | 0.29 (0.07–1.18) |
| treatment | ||
| radiation | 0.70 (0.44–1.12) | NS |
| no radiation | reference | NS |
| unknown | 0.32 (0.04–2.28) | NS |
| surgical treatment | ||
| partial/total resection | 0.61 (0.48–0.76) | 0.75 (0.59–0.95) |
| none/biopsy | reference | reference |
| unknown | 1.50 (0.83–2.73) | 1.09 (0.59–2.02) |
| unconfirmed diagnosis | ||
| age category | ||
| <20 | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) |
| 20–39 | 0.05 (0.02–0.13) | 0.5 (0.2–0.15) |
| 40–59 | 0.08 (0.06–0.11) | 0.11 (0.8–0.15) |
| 60–79 | 0.29 (0.25–0.34) | 0.34 (0.30–0.40) |
| ≥80 | reference | reference |
| sex | ||
| male | 1.3 (1.12–1.50) | 1.54 (1.31–1.80) |
| female | reference | reference |
| race | ||
| white | reference | reference |
| black | 1.23 (1.03–1.50) | 1.30 (1.08–1.57) |
| other | 0.83 (0.65–1.05) | 1.02 (0.79–1.30) |
| marital status | ||
| single | reference | reference |
| married | 0.68 (0.54–0.85) | 0.64 (0.51–0.80) |
| divorced/widowed/ separated |
1.72 (1.40–2.12) | 0.96 (0.77–1.20) |
| unknown | 0.92 (0.65–1.30) | 0.77 (0.54–1.10) |
| year of diagnosis | ||
| 2004 | 1.67 (0.93–1.47) | NS |
| 2005 | 1.03 (0.81–1.29) | NS |
| 2006 | 1.14 (0.91–1.43) | NS |
| 2007 | reference | NS |
| size of tumor (quartile) | ||
| <17 mm | reference | reference |
| 18–27 mm | 1.39 (1.06–1.58) | 1.17 (0.96–1.43) |
| 28–41 mm | 2.33 (1.90–2.84) | 1.80 (1.46–2.20) |
| ≥42 mm | 4.39 (3.53–5.46) | 3.28 (2.63–4.09) |
| unknown | 1.59 (1.32–1.91) | 1.51 (1.26–1.83) |
| side of tumor | ||
| midline | reference | NS |
| left | 1.10 (0.89–1.38) | NS |
| right | 0.92 (0.74–1.51) | NS |
| bilateral | 1.29 (0.79–2.10) | NS |
| unknown | 1.13 (0.64–2.02) | NS |
| treatment | ||
| radiation | 0.30 (0.22–0.41) | 0.46 (0.33–0.64) |
| no radiation | reference | reference |
| unknown | 0.72 (0.37–1.38) | 1.75 (0.65–4.69) |
*
NS = not significant. Bolded values indicate statistical significance (p < 0.05). Reference = reference group used to calculate the hazard ratio.