Table 4.
Examples of common medications that can modify serum theophylline levels.40
| Medication class | Increase serum theophylline levels | Decrease serum theophylline levels |
|---|---|---|
| Asthma/allergy | Zafirlukast Zileuton |
|
| Antibiotics | Ciprofloxacin, Norfloxacin, Ofloxacin Isoniazid Macrolides (except azithromycin, telithromycin) Thiabendazole |
Protease inhibitors Rifampin |
| Anti-metabolites | Allopurinol Methotrexate |
|
| Cardiovascular | Amiodarone Mexiletene Propafenone |
|
| Neurologic | Barbiturates Carbamazepine Phenytoin |
|
| Miscellaneous | Cimetidine Disulfiram Estrogens Pentoxyfylline |