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. 2011 Nov 4;1(11):e38. doi: 10.1038/bcj.2011.37

Figure 1.

Figure 1

The comparison of sensitivity to TNF-α between MLL–AFF1-positive ALL cell lines and MLL–AFF1-negative ALL cell lines. (a) Cell count ratio (TNF-α(+)/TNF-α(−)) of MLL–AFF1-negative cell line (SEM and RS4;11) and MLL–AFF1-negative cell line (MOLT4, Raji, H9, NAMALWA, Hs Sultan). TNF-α (5 ng/ml) significantly inhibited the proliferation of cell lines only in MLL–AFF1-negative cell lines (P<0.001). (b) Inhibition rate by TNF-α (5 ng/ml) of leukemia cell line. The apoptotic rate of MLL–AFF1-positive ALL cell lines 48 h after addition of TNF-α (5 ng/ml) were significantly lower than those of MLL–AFF1-negative leukemia cell lines.