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. 2011 Nov 22;287(2):1269–1278. doi: 10.1074/jbc.M111.308783

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Comparison of the antibody and TCR footprints. A, superposition of the ternary αGalCer-mCD1d complexes with bound L363 Fab (green), Vα14Vβ8.2 (Protein Data Bank ID 3ARF, orange), and Vα14Vβ7 (Protein Data Bank ID 3HE7, magenta) illustrates a binding orientation between L363 and TCRs. B, the CDR loops of L363 (L1–3 and H1–3 in green) do not overlay well with those of the two TCRs (left panel, CDR1–3α and 1–3β, colored as in A) but result in a similar overall footprint. L363 footprint is colored by individual CDR loops (top right panel). Green, L1; magenta, L2; blue, L3; orange, H1; yellow, H3. The lower panels depict shared footprint with the TCR (cyan), L363-only contacts (orange), and TCR-only contacts (light blue).