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Phosphobase methylation and domain arrangement in the PMT family. A, the PMT pathway showing the sequential methylation of pEA to pCho. SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine. B, organization of the methyltransferase (MT) domains in the plant, Plasmodium, and nematode PMT is shown. MT-1 domains catalyze the conversion of pEA to pMME, and MT-2 domains catalyze the reactions from pMME to pCho. 100 aa, 100 amino acids.
