. 2011 Oct 31;3(1):5–9. doi: 10.1021/ml200232c

Table 2. Activity of THIQ Derivative 9c as an Inhibitor of Tubulin Polymerization and Colchicine Binding to Tubulin^a.

		inhibition of colchicine binding
	inhibition of tubulin assembly	% inhibition ± SD
compd	IC₅₀ (μM) ± SD	5 μM	50 μM
CA-4	1.3 ± 0.1	98 ± 0.6
12a	2.5 ± 0.1	24.5 ± 5	74 ± 4
12b	1.3 ± 0.1	78 ± 0.9
9c	15 ± 1	13 ± 2	59 ± 2

Data for 12b are taken from ref (8).

Table 2. Activity of THIQ Derivative 9c as an Inhibitor of Tubulin Polymerization and Colchicine Binding to Tubulina.