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. 2011 Nov 21;208(12):2357–2366. doi: 10.1084/jem.20111171

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© 2011 Caskey et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Poly ICLC reliably induces IFN signaling in healthy volunteers. (a) Heat map representation of the normalized expression values. Genes shown are the top 50 differentially expressed at day 1 (FC > 2 at 5% FDR), the group-level peak time point (poly ICLC n = 8 or placebo n = 4). Each volunteer who received poly ICLC (horizontal rows) is represented at the volunteer-specific peak time (right labels), as in Fig. S2. IRGs are highlighted in red. *, genes discussed in the text. (b) Heat map representation of the between-subject correlation of the expression values for IRGs at subject-specific peak times after poly ICLC administration. The color gradient extends from pink, representing perfect correlation (or a correlation distance r of 0, i.e., 1 − r = 0), to cyan for low correlation.