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. 2011 Nov 21;208(12):2357–2366. doi: 10.1084/jem.20111171

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© 2011 Caskey et al.

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Figure 5. — Poly ICLC activated similar innate immune pathways as YF17D. (a) Differentially expressed genes (DEGs) after poly ICLC (n = 8, versus placebos; n = 4, at same time points) or YF17D (versus day 0, n = 15; Gaucher et al., 2008) at several time points after administration. The threshold of differential expression is set at FDR 5%, with either FC > 2 (solid line) or FC > 1.3 (dashed line). Peak transcriptional changes are shown after poly ICLC (212 DEGs, day 1) and YF17D (78 DEGs, day 7). (b) Heat map showing statistically significant canonical pathways (Ingenuity Pathway Analysis Software) commonly regulated by poly ICLC and YF17D at least at four different time points. Columns represent time points after either poly ICLC or YF17D. Rows represent significantly regulated canonical pathways. Heat map colors represent the ratio of regulated genes/pathway genes after poly ICLC or YF17D (pathways not overrepresented are dark blue). Maximum pathway modulation similarity was obtained between poly ICLC at day 1 and YF17D at day 7. Pathways were significantly regulated at 7 of 14 different time points analyzed (green) and at 6, 5, and 4 time points in red, blue, and black, respectively. The overrepresentation test was performed using Fisher’s Exact Test. Statistical significance was achieved at P < 0.05.