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. 2011 Nov 21;208(12):2477–2488. doi: 10.1084/jem.20111242

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© 2011 Jung et al.

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Figure 3. — Assessment of graft survival in humanized mice. Porcine islets were transplanted under the renal capsule of humanized mice that had been rendered diabetic by STZ or were nondiabetic and received an injection of isotype-matched irrelevant control or MD-3 antibody (Ab). (A) Experimental protocol. (B) Fasting blood glucose (open circles; right y axis) and porcine C-peptide (closed squares; left y axis) levels were monitored weekly. (C) Based on serum level of porcine C-peptide, functional survival of islet xenografts was plotted over time. The dotted line indicates the day when a portion of the mice were sacrificed for ELISPOT and histopathological analyses. (D) Serial kidney sections of a representative mouse in the control or MD-3–treated groups were stained with H&E or antibodies specific for insulin, human CD3, or human CD68. Bar, 100 µm.