Figure 1.

Human AGM region-derived HSCs provide progressive growth of hematopoietic contribution in NSG mice. (A) Representative flow cytometry plots show hematopoietic cells in the peripheral blood and BM of an NSG mouse transplanted with 0.33 e.e. of AGM region cells. In this case, the AGM region was obtained from a CS 16 embryo. The repopulation kinetics was monitored for 8 mo. hCD45, human CD45. (B) Human hematopoietic engraftment kinetics in the peripheral blood of 10 NSG recipient mice transplanted with human AGM region or yolk sac cells. The numbers at the end of the time series correspond to the recipient identification numbers in Table II.