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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2010 Dec 31;3(4):429–445. doi: 10.1002/wsbm.129
Neuraminidase Inhibitors (NIs) Adamantanes
When NIs are given, they are assumed to reduce the rate of viral production, p, from infected cells with efficacy εNI, with εNI = 1 corresponding to 100% effectiveness [2, 39]:
p(1εNI)p (9)
When adamantane antiviral drugs are given, they are assumed to reduce the rate of cell infection, β, with efficacy εA [6]:
β(1εA)β (10)