Table 4.
Gross Scores.
| Gross Scores | KLD | KLD+CF | KLD+CF+BMSCs | Two-way P-values | |||
|---|---|---|---|---|---|---|---|
| Feature | treated n=6 | untreated n=6 | treated n=6 | untreated n=6 | treated n=7 | untreated n=7 | |
| I. Joint Observation | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| II. Incision Appearance | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| III. Muscle wastage at the time of necropsy in treated vs untreated limbs (circumference in cm) | 12.8 (12.2, 13.4) | 12.4 (11.8, 13.0), p=0.010 | 12.8 (12.2, 13.4) | 12.7 (12.1, 13.3), p=0.530 | 13.0 (12.5, 13.6) | 12.9 (12.4, 13.5), p=0.049 |
TXT: 0.001 Group: 0.553 TXT*Group: 0.032 |
| IV. Angle of Stifle: Change in normal angle (if any) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| V. Inflammation/Swelling | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| VI. Trauma/Damage | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| VII. Infection/Discharge | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| VIII. Osteophytes and other Osteoarthritic Changes | 0.0 (−0.3, 0.3) | 0.0 (−0.3, 0.3), p=1.000 | 0.2 (−0.2, 0.5) | 0.2 (−0.2, 0.5), p=1.000 | 0.6 (0.3, 0.9) | 0.6 (0.3, 0.9), p=1.000 |
TXT: 1.000 Group: 0.029 TXT*Group: 1.000 |
| IX. Articular Surface Integrity, Contour, and Congruity | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| X. Presence of Loose Bodies in Synovial Fluid | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| XI. Injury to Apposing Articular Surface | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| XII. Synovial Membrane | 0.5 (0.0, 1.0) | 0.3 (−0.1, 0.8), p=0.611 | 0.2 (−0.3, 0.6) | 0.3 (−0.1, 0.8), p=0.562 | 0.1 (−0.3, 0.6) | 0.3 (−0.1, 0.7), p=0.356 |
TXT: 0.750 Group: 0.685 TXT*Group: 0.605 |
| XIII. Cartilage Attachment to surrounding cartilage | 0.7 (0.0, 1.4) | 1.0 (0.3, 1.7), p=0.530 | 0.5 (−0.2, 1.2) | 0.3 (−0.4, 1.0), p=0.611 | 0.4 (−0.2, 1.1) | 1.0 (0.3, 1.7), p=0.172 |
TXT: 0.299 Group: 0.541 TXT*Group: 0.423 |
| XIV. Bone Attachment | 0.3 (−0.3, 1.0) | 0.7 (0.0, 1.3), p=0.363 | 0.7 (0.0, 1.3) | 0.5 (−0.1, 1.1), p=0.695 | 0.3 (−0.3, 0.9) | 0.9 (0.3, 1.5), p=0.030 |
TXT: 0.192 Group: 0.970 TXT*Group: 0.262 |
| XV. Firmness | 0.7 (−0.1, 1.5) | 0.8 (0.0, 1.6), p=0.741 | 1.0 (0.2, 1.8) | 0.5 (−0.3, 1.3), p=0.296 | 0.4 (−0.3, 1.2) | 1.0 (0.3, 1.7), p=0.172 |
TXT: 0.750 Group: 0.995 TXT*Group: 0.222 |
| XVI. Blood | 3.0 (2.9, 3.1) | 3.0 (2.9, 3.1), p=1.000 | 3.0 (2.9, 3.1) | 3.0 (2.9, 3.1), p=1.000 | 3.0 (2.9, 3.1) | 2.9 (2.7, 3.0), p=0.356 |
TXT: 0.384 Group: 0.449 TXT*Group: 0.449 |
| XVII. Shape | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| XVIII. Grade (Overall quality of repair) | 3.2 (2.3, 4.0) | 2.2 (1.3, 3.0), p=0.076 | 2.7 (1.8, 3.5) | 2.8 (2.0, 3.7), p=0.818 | 3.3 (2.5, 4.0) | 2.4 (1.7, 3.2), p=0.017 |
TXT: 0.061 Group: 0.896 TXT*Group: 0.220 |
| XIX. Level | 2.7 (2.0, 3.3) | 2.0 (1.3, 2.7), p=0.102 | 2.5 (1.8, 3.2) | 2.3 (1.7, 3.0), p=0.695 | 2.7 (2.1, 3.3) | 2.3 (1.7, 2.9), p=0.200 |
TXT: 0.050 Group: 0.897 TXT*Group: 0.613 |
| XX. Color | 5.8 (4.7, 6.9) | 4.7 (3.6, 5.8), p=0.126 | 4.8 (3.7, 5.9) | 4.8 (3.7, 5.9), p=1.000 | 5.9 (4.8, 6.9) | 5.3 (4.3, 6.3), p=0.231 |
TXT: 0.182 Group: 0.363 TXT*Group: 0.547 |
| XXI. Surface | 1.8 (1.2, 2.5) | 2.2 (1.5, 2.8), p=0.465 | 1.5 (0.8, 2.2) | 2.0 (1.3, 2.7), p=0.296 | 1.7 (1.1, 2.3) | 2.0 (1.4, 2.6), p=0.457 |
TXT: 0.127 Group: 0.753 TXT*Group: 0.925 |
| XXII. Area | 94.2 (80.2, 108.2) | 90.0 (76.0, 104.0), p=0.383 | 95.7 (81.7, 109.7) | 90.0 (76.0, 104.0), p=0.441 | 97.1 (84.2, 110.1) | 82.9 (69.9, 95.8), p=0.276 |
TXT: 0.138 Group: 0.902 TXT*Group: 0.681 |
| XXIII. Volume | 91.7 (75.6, 107.8) | 71.7 (55.6, 87.8), p=0.058 | 88.2 (72.1, 104.3) | 80.8 (64.7, 96.9), p=0.477 | 94.3 (79.4, 109.2) | 82.1 (67.2, 97.0), p=0.297 |
TXT: 0.032 Group: 0.706 TXT*Group: 0.667 |
One-way p-values for within group comparisons are listed in the untreated columns. Two-way p-values for differences among groups are in a separate column (TXT = treatment, Group = group, TXT*Group = interaction term). P-values are not shown when all the scores being compared are zero. Mean and confidence intervals calculated during two-way analysis are shown.