Table 5.
Histological Scores.
| Histology Scores | KLD | KLD+CF | KLD+CF+BMSCs | Two-way P-values | |||
|---|---|---|---|---|---|---|---|
| Feature | treated n=6 | untreated n=6 | treated n=6 | untreated n=6 | treated n=7 | untreated n=7 | |
| I. Nature of the Repair Tissue | 1.0 (0.4, 1.6) | 0.7 (0.1, 1.3), p=0.363 | 0.7 (0.1, 1.3) | 0.7 (0.1, 1.3), p=1.000 | 0.9 (0.3, 1.4) | 0.4 (−0.1, 1.0), p=0.134 |
TXT: 0.264 Group: 0.749 TXT*Group: 0.710 |
| II. Surface Regularity | 2.5 (1.8, 3.2) | 2.2 (1.5, 2.9), p=0.175 | 2.0 (1.3, 2.7) | 1.7 (1.0, 2.4), p=0.465 | 1.4 (0.8, 2.1) | 0.9 (0.2, 1.5), p=0.298 |
TXT: 0.130 Group: 0.005 TXT*Group: 0.906 |
| III. Structural Integrity | 1.3 (0.9, 1.7) | 1.0 (0.6, 1.4), p=0.175 | 1.2 (0.8, 1.6) | 1.2 (0.8, 1.6), p=1.000 | 0.9 (0.5, 1.2) | 0.7 (0.3, 1.1), p=0.563 |
TXT: 0.284 Group: 0.118 TXT*Group: 0.655 |
| IV. Thickness | 1.7 (1.1, 2.2) | 1.2 (0.6, 1.7), p=0.237 | 1.5 (1.0, 2.0) | 1.7 (1.1, 2.2), p=0.611 | 1.3 (0.8, 1.8) | 1.3 (0.8, 1.8), p=1.000 |
TXT: 0.583 Group: 0.478 TXT*Group: 0.396 |
| V. Bonding to Adjacent Cartilage | 0.7 (0.1, 1.3) | 1.0 (0.4, 1.6), p=0.363 | 1.3 (0.7, 1.9) | 1.3 (0.7, 1.9), p=1.000 | 0.6 (0.0, 1.1) | 1.0 (0.4, 1.6), p=0.200 |
TXT: 0.161 Group: 0.226 TXT*Group: 0.580 |
| VI. Hypocellularity | 1.7 (1.3, 2.1) | 1.3 (0.9, 1.7), p=0.175 | 1.7 (1.3, 2.1) | 1.3 (0.9, 1.7), p=0.175 | 2.0 (1.6, 2.4) | 2.0 (1.6, 2.4), p=1.000 |
TXT: 0.031 Group: 0.081 TXT*Group: 0.259 |
| VII. Chondrocyte Clustering | 1.7 (1.3, 2.0) | 1.8 (1.5, 2.2), p=0.363 | 1.7 (1.3, 2.0) | 1.7 (1.3, 2.0), p=1.000 | 1.9 (1.5, 2.2) | 2.0 (1.7, 2.3), p=0.356 |
TXT: 0.364 Group: 0.397 TXT*Group: 0.809 |
| VIII. Freedom from Degenerative Changes in Adjacent Cartilage | 1.7 (1.2, 2.2) | 1.8 (1.3, 2.3), p=0.611 | 1.8 (1.3, 2.3) | 2.2 (1.7, 2.7), p=0.363 | 1.3 (0.8, 1.8) | 1.0 (0.5, 1.5), p=0.172 |
TXT: 0.658 Group: 0.015 TXT*Group: 0.270 |
| IX. Reconstitution of Subchondral Bone | 1.8 (1.2, 2.4) | 1.5 (0.9, 2.1), p=0.363 | 2.2 (1.6, 2.8) | 2.0 (1.4, 2.6), p=0.695 | 1.6 (1.0, 2.1) | 0.9 (0.3, 1.4), p=0.074 |
TXT: 0.074 Group: 0.030 TXT*Group: 0.556 |
| X. Inflammatory Response in Subchondral Bone Region | 2.0 (1.9, 2.1) | 1.8 (1.7, 2.0), p=0.363 | 2.0 (1.9, 2.1) | 2.0 (1.9, 2.1), p=1.000 | 2.0 (1.9, 2.1) | 2.0 (1.9, 2.1), p=1.000 |
TXT: 0.306 Group: 0.358 TXT*Group: 0.358 |
| XI. Safranin-O Staining | 1.2 (0.6, 1.7) | 0.2 (−0.4, 0.7), p=0.012 | 0.3 (−0.2, 0.9) | 0.5 (−0.0, 1.0), p=0.611 | 0.3 (−0.2, 0.8) | 0.6 (0.1, 1.1), p=0.337 |
TXT: 0.286 Group: 0.604 TXT*Group: 0.011 |
| XII. Cumulative Histology Score (sum of above scores) | 17.2 (14.8, 19.5) | 14.5 (12.2, 16.8), p=0.034 | 16.3 (14.0, 18.7) | 16.2 (13.8, 18.5), p=0.915 | 14.0 (11.8, 16.2) | 12.7 (10.5, 14.9), p=0.417 |
TXT: 0.140 Group: 0.030 TXT*Group: 0.541 |
One-way p-values for within group comparisons are listed in the untreated columns. Two-way p-values for differences among groups are in a separate column (TXT = treatment, Group = group, TXT*Group = interaction term). Mean and confidence intervals calculated during two-way analysis are shown.