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. 2011 Aug 3;80(10):1064–1072. doi: 10.1038/ki.2011.257

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Copyright © 2011 International Society of Nephrology

This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Neutrophil response, epithelial damage, and neutrophil accumulation in the kidneys of infected mCxcr2^+/+ and mCxcr2^+/− mice. (a) Early subepithelial neutrophil influx in wild-type mice after 6 h of infection. Wild-type mice show intact epithelium and no neutrophil accumulation. (b) Delayed subepithelial neutrophil influx (arrows) and neutrophil accumulation (^*) 7 days after infection in heterozygous mice. Proliferating epithelium was observed 14 days after infection in mCxcr2^+/− mice. Hematoxylin–eosin staining (left panel) and immunohistochemistry, using the monoclonal granulocyte-specific antibody (RB6-8C5; right panel). IF, infiltrate.