Figure 6.

The CoMFA contour map of model 2 combined with compound 73. (a) Steric field distribution on the background of protein surface; and (b) electrostatic field distribution on the background of electrostatic potential surface colored from purple to red owing to the increase of electron density. Green contours indicate regions where bulky groups increase activity, whereas yellow contours indicate regions where bulky groups decrease activity. Red contours suggest negative charge favoring activity, whereas blue contours suggest positive charge favoring activity.