Table 1.

Structures of 73 compounds.

Compound	R1	R2	R3	R4
1 *	NHMe	Me	H	H
2 *	NHcyclopropyl	Me	H	H
3	NHcyclopentyl	Me	H	H
4	NHPh	Me	H	H
5	NH2	Me	CF3	H
6	NH2	Ph	H	H
7	NH2	i-Pr	H	H
8	NH2	1-methylpiperidine-4-yl	H	H
9	NH2	2-(piperidin-1-yl)-ethyl	H	H
10*	NH2	Me	H	m-CF3
11	NH2	Me	H	p-CF3
12	NH2	Me	Ac	H
13	NH2	Me	H	m-Ac
14	NH2	Me	OMe	H
15	NH2	Me	H	m-OMe
16	NH2	Me	H	p-OMe
17	NH2	Me	NO2	H
18	NH2	Me	H	m-NO2
19	NH2	Me	Me	H
20 *	NH2	Me	NHMe	H
21	NH2	Me	i-Pr	H
22 *	NH2	Me	COOMe	H
23 *	NH2	Me	CONH2	H
24	NH2	Me	SO2NH2	H
25	NH2	Me	Ph	H
26 *	NH2	Me	OPh	H
27	NH2	Me	benzyl	H
28 *	NH2	Me	NHPh	H
29	NH2	Me	benzoyl	H
30 *	NH2	Me	SPh	H
31	NH2	Me	Ac	3′-(4-methyl-piperazin-1-yl)
32 *	NH2	Me	Ac	4′-(4-methyl-piperazin-1-yl)
33	NH2	Me	Ac	5′-(4-methyl-piperazin-1-yl)
34	NH2	Me	OMe	4′-(4-methyl-piperazin-1-yl)
35 *	NH2	Me	OMe	5′-(4-methyl-piperazin-1-yl)
36	OEt	Me	H	H
37	NH2	Me	NH2	H
38	NH2	Me	NHAc	H
39	NH2	Me	OCF3	H
40	NH2	Me	OCF3
41 *	NH2	Me	OCF3
42	NH2	Me	OCF3
43	NH2	Me	OCF3
44	NH2	Me	OCF3
45	NH2	Me	OCF3
46 *	NH2	Trityl	OCF3
47	NH2	H	OCF3
48 *	NH2	2-Fluoro-ethyl	OCF3
49	NH2	Ethyl	OCF3
50 *	NH2	2-Methoxy-ethyl	OCF3
51	NH2	2-Chloro-ethyl	OCF3
52	NH2	Vinyl	OCF3
53 *	NH2	Me	OCF3
54	NH2	Me	OCF3	5′-NH2
55	NH2	Me	OCF3
56 *	NH2	Me	OCF3
57	NH2	Me	OCF3
58	NH2	Me	OCF3
59	NH2	Me	OCF3
60	NH2	Me	OCF3
61	NH2	Me	OCF3
62 *	NH2	Me	OCF3
63	NH2	Me	OCF3
64 *	NH2	Me	OCF3
65	NH2	Me	OCF3
66 *	NH2	Me	OCF3
67	NH2	Me	OCF3
68	NH2	Me	OCF3
69	NH2	−(CH2)3–N–(CH3)2	OCF3
70 *	NH2		OCF3
71	NH2	− (CH2)2–NH2	OCF3
72	NH2	− (CH2)3–NH2	OCF3
73	NH2	− (CH2)2–OH	OCF3

^*Compounds in test set.