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The 3D structure of human histone deacetylase 8 (HDAC8) bound with an inhibitor (PDB code 2V5X). A zoomed view of inhibitor binding region shows the tunnel-like active site in mesh form. The hydroxamic acid part of inhibitor binds close to the metal (Zn2+) ion whereas the aliphatic chain and hydrophobic cap groups occupy the tunnel and surface of the active site.
