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. 2011 Nov 23;31(47):17028–17039. doi: 10.1523/JNEUROSCI.1268-11.2011

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Copyright © 2011 the authors 0270-6474/11/3117028-12$15.00/0

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Figure 5. — Intracisternal injection of the serotonin neurotoxin 5,7-DHT partially reversed mechanical hypersensitivity after SNL. A, Withdrawal thresholds became significantly higher after rats receiving SNL were injected with 5,7-DHT. Also, thresholds were significantly higher in rats receiving SNL that were treated with 5,7-DHT than in rats receiving SNL that were given saline (*p < 0.05; two-way ANOVA). B, Image of 5-HT immunoreactivity in superficial dorsal horn of a rat that had received SNL and that was treated with 5,7-DHT (compare to Fig. 4D). Note lack of 5-HT immunoreactivity. Box in inset denotes area from which image was obtained.