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. 2011 Nov 23;31(47):17028–17039. doi: 10.1523/JNEUROSCI.1268-11.2011

Figure 7.

Figure 7.

TUDCA prevented neuronal loss after SNL, including serotonergic cell loss, and partially reversed SNL-induced mechanical hypersensitivity. A, Compared with vehicle-treated rats, TUDCA-treated rats had significantly more Nissl-stained neurons ipsilateral to SNL (*p < 0.05, two-way ANOVA). B, TUDCA-treated rats also had significantly more TPH-IR neurons after SNL (*p < 0.05, two-way ANOVA). In contrast to saline-treated rats, there were no significant differences between the numbers of RVM neurons ipsilateral and contralateral to SNL in TUDCA-treated animals. C, Beginning 4 d post-SNL, the withdrawal thresholds of the ipsilateral hindpaws of TUDCA-treated rats were significantly higher than those in animals treated with saline (p < 0.05; two-way ANOVA). There were no significant differences between the withdrawal thresholds of the contralateral hindpaws at any time point. Inverted triangles, Contralateral saline; squares, contralateral TUDCA; circles, ipsilateral TUDCA; triangles, ipsilateral saline.