Figure 8.

SNL induced a bilateral activation of astrocytes and microglia and an increase in glial number. A–D, At day 3, astrocytes were activated (as shown by increased GFAP labeling) in the ipsilateral and contralateral RVM after SNL, compared with sham. E–H, At day 10, microglia were activated after SNL compared with sham, as shown by increased labeling for the microglial marker, CD11b. I, We observed significantly more Nissl-stained glia in the RVM after SNL and the increase was bilateral. J, No significant increases in glial number were found in Facial nucleus after SNL. Scale bar in H applies to A–H.