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. 2012 Jan 12;7(1):e28568. doi: 10.1371/journal.pone.0028568

Figure 3. Mechanism of action predictions using cDNA microarray-based cluster analysis.

Figure 3

A) Cluster analysis. Data from CCT020312 and 22 other molecularly targeted agents, 296 samples in total, established using either the CRUK Human Whole Genome-wide Array v1.0.0 or the CRUKDMF_22K_v1.0.0 array were used. Genes that significantly varied with treatment (ANOVA p<0.05 with Bonferoni-correction) were used for hierarchical clustering. Clustering was performed using the Euclidian distance as a similarity measure. B) Cluster deconvolution. Conditions that cluster with (Cluster I) or adjacent to (Cluster II) CCT020312 are shown.