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. 2012 Jan 12;7(1):e29495. doi: 10.1371/journal.pone.0029495

Figure 2. Positional cloning of the chromosome 14 Ecl gene.

Figure 2

CSS-14 offspring were phenotyped as circling or non-circling and genotyped at SSLP markers across chromosome 14. Due to incomplete penetrance of the circling phenotype, only circlers were used to narrow the candidate interval. Blue bars depict regions of SWR homozygosity in CSS-14 circlers; each bar represents multiple circling mice with the same genotype. The Ecl candidate gene interval (red bar) was defined as the region of SWR homozygosity common to all CSS-14 circlers. This interval spans 445 Kb from D14Kar16 to D14Kar40 and includes five annotated genes and four spliced ESTs (bottom panel). The coding sequence of Bmp4 was excluded from the candidate interval by two independent crossovers.