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. 2012 Jan 12;7(1):e29495. doi: 10.1371/journal.pone.0029495

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Roberts et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Rubie (EST BY232928) sequence displayed in genomic databases is derived from a partially-sequenced RIKEN cDNA clone and includes 388 bp, divided among three exons. Resequencing of the RIKEN clone revealed a full-length insert of 1404 bp, divided among five exons. (B) Expression of Rubie in embryonic (E15.5) and postnatal (P6) mouse inner ears was confirmed by RT-PCR. Expression was not observed in P6 hindbrain. The bottom PCR band represents use of an alternative splice site between exons 1 and 2 of Rubie. (C) Rubie expression was detected in the three sensory cristae (anterior crista, AC; lateral crista, LC; posterior crista, not shown) and the developing cochlea (Co) of sectioned E11.5 embryos by in situ hybridization. (D) No signal was detected using a Rubie sense control probe. Rubie (E) and Bmp4 (F) exhibited similar expression patterns in the developing inner ear.