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. 2012 Jan 12;7(1):e29856. doi: 10.1371/journal.pone.0029856

Figure 5. Pro-inflammatory cytokines were up-regulated in animals which produced ureaplasma-specific ureaplasma antibodies.

Figure 5

The relative expression of IL-1β, IL-6 and IL-8 within the chorioamnion was significantly increased in ewes that tested positive for anti-ureaplasma IgG antibodies (IgG positive) within serum samples, when compared to animals in which these antibodies were not generated (IgG negative) (A). Conversely, the relative expression of TNF-α and IL-10 (B); and TLR1, TLR2 and TLR6 (C) within the chorioamnion were decreased in IgG negative animals when compared to IgG positive animals. Data are presented as mean fold change ± SEM. * p<0.05. Expression of genes is determined relative to the expression of GAPDH after normalisation against 10B medium control animals.