Table 1. Allelic analyses of the 23 tag SNPs genotyped in CCALD and AMN patients.

SNP (dbSNP31)	MAF	MAF AMN	MAF CCALD	χ2	P value	empirical P valueb	Odds ratio [CI95%]
rs3021477	0.39	0.41	0.38	0.32	0.573	-	0.87 [0.53 ; 1.42]
rs3754471	0.49	0.43	0.53	2.4	0.121	-	1.47 [0.90 ; 2.40]
rs859010	0.08	0.13	0.06	3.91	0.069a	0.064	0.42 [0.18 ; 1.01]
rs692565	0.41	0.42	0.41	0.06	0.805	-	0.94 [0.57 . 1.54]
rs1748363	0.15	0.19	0.13	2.2	0.138	-	0.61 [0.31 ; 1.18]
rs973742	0.40	0.50	0.33	7.56	0.006	0.008	0.50 [0.30 ; 0.82]
rs429201	0.16	0.20	0.13	2.38	0.123	-	0.60 [0.32 ; 1.15]
rs366316	0.16	0.17	0.14	0.43	0.512	-	0.80 [0.41 ; 1.55]
rs2269715	0.04	0.07	0.02	-	-	-	-
rs440419	0.19	0.24	0.16	2.26	0.133	-	0.63 [0.35 ; 1.15]
rs1230716	0.41	0.44	0.39	0.88	0.347	-	0.79 [0.48 ; 1.29]
rs12033535	0.03	0.03	0.03	-	-	-	-
rs1590230	0.16	0.16	0.16	0.003	0.956	-	0.98 [0.51 ; 1.90]
rs10797007	0.28	0.34	0.24	2.94	0.086	0.117	0.62 [0.67 ; 1.07]
rs3181082	0.11	0.16	0.07	5.33	0.028a	0.031	0.41 [0.19 ; 0.89]
rs2317955	0.10	0.15	0.08	4.36	0.043a	0.054	0.44 [0.20 ; 0.97]
rs1065457	0.28	0.33	0.25	2.07	0.15	-	0.68 [0.40 ; 1.15]
rs12742463	0.08	0.10	0.08	0.39	0.654a	-	0.76 [0.32 ; 1.80]
rs12139388	0.08	0.09	0.08	0.03	1a	-	0.92 [0.39 ; 2.22]
rs11801558	0.08	0.08	0.08	0.005	1a	-	0.97 [0.39 ; 2.42]
rs7547997	0.11	0.11	0.11	0.06	1a	-	1.10 [0.50 ; 2.39]
rs11264965	0.18	0.19	0.17	0.29	0.587	-	0.84 [0.45 ; 1.58]
rs12756570	0.06	0.06	0.05	0.29	0.589	-	0.76 [0.27 ; 2.09]

^a: The Fisher's exact test was used for SNP with a Minor Allele Frequency (MAF)<0.10.

^b: Permutation-based empirical P value were calculated for SNP showing a trend of association (P value<0.10).