Table 2. Descriptive characteristics of 13 girls with newly diagnosed brain pathology.

ID	CPP according to criteria	MRI findings	Age at onset (years)	Age at 1st exam (years)	Pubertal stage	Height (SDS)	Weight (SDS)	BMI (SDS)	BA-CA (years)	Basal FSH (IU/L)	Peak FSH (IU/L)	Basal LH (IU/L)	Peak LH (IU/L)	Peak LH/FSH ratio	E2 (pmol/L)	GnRH agonist therapy	Clinical Outcome
1	y	Chiari II malformation	6.2	7.9	B3	0,7	ND	ND	3,1	4,45	11,9	1,54	25,4	2.13	53	y	clinical follow up
2	y	Hypothalamic hamartoma	6.4	11.0	B4	0,9	0,8	0,9	2.5	1,6	ND	2,34	ND	ND	611	n	MRI follow up
3	y	Pilocytic astrocytoma	6.5	6.9	B3	1.3	0.8	0.2	−1	2,31	8,94	0,15	13,3	1.48	36	y	Operation
4	n	Hamartomas (basal ganglia, brain stem, cerebellum), NF type 1	7.0	7.7	B1	1,1	1,3	1,1	1,3	1,73	5,62	0,06	1,56	0.28	18	n	clinical follow up
5	y	Arachnoid cyst	7.5	9.9	B3	1,5	2,4	1,5	3,1	2,12	ND	1,13	ND	ND	227	n	MRI follow up
6	y	Pontine tumor	7.5	7.9	B2	1,4	1,9	1,5	2,5	1,8	5,32	0,72	10,7	2.01	30	y	MRI follow up
7	y	Hydrocephalus and arachnoid cyst	7.6	8.0	B2	0,7	1,6	1,3	−0,1	3.77	9.47	0.89	12.5	1.32	61	y	MRI follow up
8	n	Arachnoid cyst	8.2	9.0	B4	1,4	4,1	2,8	2,0	4,39	ND	3,97	ND	ND	47	y	MRI follow up
9	n	Hydrocephalus and corpus callosum agenesia	8.3	9.7	B3	−2	0,1	1,6	1,3	5,79	17	5,47	63,3	3.72	100	y	clinical follow up
10	n	Congenital dysplasia in left occipital lobe	8.5	9.5	B5	0,3	0,8	1	1,5	5,43	6,77	4,4	21,3	3.15	184	y	MRI follow up
11	n	Arachnoid cyst	8.5	9.0	B2	2,2	1,2	0,1	1,7	8,56	14,8	1,41	28,5	1.93	62	y	MRI follow up
12	n	Arachnoid cyst	8.5	9.1	B2	0,9	2,1	1,8	0,5	2,28	8,69	0,12	8,85	1.02	18	n*	MRI follow up
13	n	Pineal tumor	8.5	9.5	B3	1,4	ND	ND	0.5	5,03	ND	1,18	ND	ND	160	y	MRI follow up

y: yes, n:no, ND: Not Determined,

*: indicated but parental decline.