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. 2012 Jan 12;7(1):e30134. doi: 10.1371/journal.pone.0030134

Figure 3. Cytokine mRNA expressions in liver, lung and spleen.

Figure 3

Tissues from the liver, lung and spleen in experimental mice at 5 hours after lipopolysaccharide (LPS) injection showed increased mRNA expressions of interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), monocyte chemotactic protein (MCP)-1 and tumor necrosis factor (TNF)-α in LPS-injected mice. Treatment with aldose reductase inhibitor (ARI) either before or after the injection of LPS significantly suppressed the elevations of all the cytokines. The alterations were all similar in the liver, lung and spleen. Overall, there was no significant difference in mRNA expressions between pretreated and posttreated groups except for IL-6, TNF-α in the lung and MCP-1 and TNF-α in the spleen (see text). Each group consists of 6∼8 animals. Bar stands for mean ± SE. C: Control, L: LPS-injected group, Pre: LPS+ARI-pretreatment group, Post: LPS+ARI-posttreatment group. *p<0.01 vs Control, **p<0.01 vs LPS, †p<0.05 vs LPS+ARI-pretreatment group, ‡p<0.05 vs LPS.