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. 2012 Jan 12;7(1):e30134. doi: 10.1371/journal.pone.0030134

Figure 6. Renal pathology in experimental mice stained with hematoxylin and eosin.

Figure 6

Compared to lipopolysacchrade (LPS)-free mice (a), marked vacuolar degeneration of tubular cells were noted in LPS-injected mice (b). Such vacuolar changes were markedly suppressed in either pretreated group (c) or posttreated group (d). Quantitative estimation of the degenerated cells confirmed the effects of aldose reductase inhibitor (e). Magnification of the pictures was all x320. Each group consists of 6 animals. Bar stands for mean ± SE. AU; arbitrary unit C: Control, L: LPS-injected group, Pre: LPS+ARI-pretreatment group, Post: LPS+ARI-posttreatment group. *p<0.01 vs Control, **p<0.01 vs LPS.