Table 2. Experimental evidence of phosphorylation-mediated modulation of domain-motif interactions.
Domain type | Domain-containing protein | Motif-containing protein | Phosphorylated residue | Intra/near motif | Reference |
PDZ | PSD-95 | Kir2.3 | S440 | Intra | [78] |
PSD-95 | Beta-1-adrenergic receptors | Various | Intra | [79] | |
PSD-95 | Kir5.1 | S417 | Intra | [80] | |
PSD-95 | Stargazin | T321 | Intra | [26] | |
EBP-50 | ß2-adrenergic receptor | S411 | Intra | [81] | |
Syntenin-1 | syndecan-1 | T309 | Intra | [82] | |
Syntenin-1 | syndecan-4 | S183 | Intra | [27] | |
AF6, ERBIN, SNA1 | Various | Various | Intra | [83] | |
ERBIN | ErbB2 | T1248 | Near* (3) | [16] | |
Grasp65 | Grasp65 | S189 | Near(20) | [84] | |
SH3 | Syndapin-1 | Dynamin-1 | S774 | Intra | [85] |
Endophilin-1 | Dynamin-1 | S778 | Intra | [86] | |
Nck | Pak1 | S21 | Near(5) | [12] | |
Fyn | Tau | T231 | Near(7) | [76] | |
Fyn | Tau | S210 | Near(3) | [76] | |
WW | Utrophin | ß-dystroglycan | Y892 | Intra | [15] |
Various | Smad2, Smad3 | S208, S204 | Near(17,21) | [87] |
*Numbers in parentheses indicate the distance between the motif and the proximal phosphorylation site/s.