Skip to main content
. 2011 Dec 7;31(49):18137–18148. doi: 10.1523/JNEUROSCI.3041-11.2011

Figure 3.

Figure 3.

Deficit in parvalbumin impairs gamma-band activity through asynchronous GABA release. A, Examples of synaptic response (Y) for different concentrations of parvalbumin at model synapses: the baseline model with [PV] = 100 μm (A1); [PV] = 10 μm (A2); [PV] = 0 μm (A3). Synapses were stimulated by seven spikes at 40 Hz. To facilitate presentation of asynchronous release, the phasic part of synaptic response was truncated. B, Characterization of activity in the neuron deficit model. B1, Spectral power plots of baseline model (F[PV] = 0 = 0, black) versus the F[PV] = 0 = 0.4 model (red). B2, Magnitude (blue circles) and location (green circles) of spectral power peak versus the fraction of IN neurons with zero PV. Black and red points correspond to those shown in left plot. B3, Rates of PY (black) and IN (red) neurons firing versus the F[PV] = 0. C, Characterization of activity in concentration deficit model. C1, Spectral power plots of baseline model ([PV] = 100 μm, black) versus the [PV] = 40 μm model (red). C2, Magnitude and location of spectral power peak versus the PV concentration. C3, Rates of PY (black) and IN (red) neurons firing versus the PV concentration.