Figure 4.

PV deficiency at GABA synapses prevents the disinhibition of network dynamics. A, Representative membrane potentials and LFPs obtained for scenarios of intact networks (F_{[PV] = 0} = 0), in which all model interneurons were subject to hyperpolarizing DC current I_HYP. A1–A3, Membrane potential of sample interneuron (A1), membrane potential of sample pyramidal neuron (A2), and local field potential (A3) for the case I_HYP = 0 μA/cm². B, The same as in A, but for I_HYP = 3 μA/cm². C, Network-averaged firing rates of model PY (black squares) and IN (gray circles) neurons versus the magnitude of I_HYP. Data points are averages ± SEM. D, Magnitude of spectral power peak versus the magnitude of I_HYP. E, Location of spectral power peak versus the magnitude of I_HYP.