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. 2011 Dec 7;31(49):18137–18148. doi: 10.1523/JNEUROSCI.3041-11.2011

Figure 6.

Figure 6.

Reduced GAD67 exacerbates the effect of parvalbumin deficit on network activity. A1, Spectral power plots for the scenario in which PV deficit is accompanied by reduced GABA conductance: gGABA at 100% of its baseline value and [PV] = 100 μm (solid black); gGABA at 100% of its baseline value and [PV] = 40 μm (dashed black); gGABA at 60% of its baseline value and [PV] = 100 μm (solid red); gGABA at 60% of its baseline value and [PV] = 40 μm (dashed red). A2, A3, Quantification of spectral peak power (A2) and frequency (A3) changes versus different PV concentrations and alterations in GABA conductance. Black squares, gGABA at 100% of its baseline value. Red triangles, gGABA at 60% of its baseline value. Network stimulation frequency was vSTIM = 250 Hz. B1, Spectral power plots for the scenario in which PV deficit is accompanied by slower time τR of GABA synapse recovery from depression: τR = 0.2 s and [PV] = 100 μm (solid black); τR = 0.2 s and [PV] = 40 μm (dashed black); τR = 0.4 s and [PV] = 100 μm (solid red); τR = 0.4 s and [PV] = 40 μm (dashed red). B2, B3, Quantification of spectral peak power (B2) and frequency (B3) changes versus different PV concentrations and altered time of GABA synapse recovery from depression. Black squares, τR = 0.2 s. Red triangles, τR = 0.4 s. Network stimulation frequency was vSTIM = 250 Hz. C1–C4, Firing rates of PY (C1, C3) and IN (C2, C4) model neurons for different scenarios shown in A and B. D1, Magnitude of spectral power peak (time average over stimulus duration) versus F[PV] = 0 and relative (to the baseline stimulation of v0 = 150 Hz) increase in stimulation rate. D2, Magnitude of spectral power peak (time average over 200 ms after stimulus) versus F[PV] = 0 and relative increase in stimulation rate. Color scale is the same for D1–D2. E1, Spectral power over the time duration of stimulus presentation (40 ms) for different scenarios: gGABA at 100% of its baseline value and F[PV] = 0 = 0 (solid black); gGABA at 100% of its baseline value and F[PV] = 0 = 0.4 (dashed black); gGABA at 60% of its baseline value and F[PV] = 0 (solid red); gGABA at 60% of its baseline value and F[PV] = 0 = 0.4 (dashed red). E2, Spectral power over 200 ms following stimulus cessation; keys are the same as in E1. In both E1 and E2, stimulus rate was vSTIM = 400 Hz.