Table 3.
Summary of GWAS Findings for Metabolic Traitsa
|
Prior to 2007 |
2007 onward |
|||
|---|---|---|---|---|
| Disease | Number of Loci | Loci | Number of Loci | Some or All of the Loci |
| Type 2 diabetes | 3 | PPARG, KCNJ11 (MIM 600937), TCF7L2 | 50 | NOTCH2 (MIM 600275), PROX1 (MIM 601546), GCKR, THADA (MIM 611800), BCL11A (MIM 606557), RBMS1 (MIM 602310), IRS1, ADAMTS9, ADCY5 (MIM 600293), IGF2BP2 (MIM 608289), WFS1, ZBED3, CDKAL1, DGKB (MIM 604070), JAZF1, GCK, KLF14, TP53INP1 (MIM 606185), SLC30A8 (MIM 611145), PTPRD (MIM 601598), CDKN2A, CHCHD9, CDC123, HHEX (MIM 604420), DUSP8 (MIM 602038), KCNQ1, CENTD2, MTNR1B, HMGA2 (MIM 600698), TSPAN8 (MIM 600769), HNF1A, ZFAND6 (MIM 610183), PRC1 (MIM 603484), FTO, SRR (MIM 606477), HNF1B (MIM 189907), DUSP9 (MIM 300134), CDCD4A, UBE2E2 (MIM 602163), GRB14 (MIM 601524), ST6GAL1 (MIM 109675), VPS26A (MIM 605506), HMG20A (MIM 605534), AP3S2 (MIM 602416), HNF4A (MIM 600281), SPRY2 (MIM 602466) |
| Body-mass index | 1 | MC4R | 30 | NEGR1 (MIM 613173), TNNI3K (MIM 613932), PTBP2 (MIM 608449), TMEM18 (MIM 613220), POMC, FANCL (MIM 608111), LRP1B (MIM 608766), CADM2 (MIM 609938), ETV5 (MIM 601600), GNPDA2 (MIM 613222), SLC39A8 (MIM 608732), HMGCR (MIM 142910), PCSK1, ZNF608, NCR3 (MIM 611550), HMGA1 (MIM 600701), LRRN6C, TUB (MIM 601197), BDNF, MTCH2 (MIM 613221), FAIM3 (MIM 606015), MTIF3, PRKD1 (MIM 605435), MAP2K5 (MIM 602520), FTO, SH2B1, GPRC5B (MIM 605948), KCTD15, GIPR, TMEM160 |
| Glucose or insulin | 1 | GCK | 15 | GCKR, G6PC2, IGF1, ADCY5 (MIM 600293), MADD (MIM 603584), ADRA2A, CRY2 (MIM 603732), FADS1 (MIM 606148), GLIS3 (MIM 610192), SLC2A2, PROX1 (MIM 601546), C2CD4B (MIM 610344), DGKB (MIM 604070), GIPR, VPS13C (MIM 608879) |
| Fat distribution | 0 | 20 | TBX15 (MIM 604127), LYPLAL1, IRS1, SPRY2 (MIM 602466), GRB14 (MIM 601524), STAB1 (MIM 608560), ADAMTS9, CPEB4 (MIM 610607), VEGFA (MIM 192240), TFAP2B (MIM 601601), LY86 (MIM 605241), RSPO3 (MIM 610574), NFE2L3 (MIM 604135), MSRA (MIM 601250), ITPR2 (MIM 600144), HOXC13 (MIM 142976), NRXN3 (MIM 600567), ZNRF3 (MIM 612062), PIGC (MIM 601730) | |
| Total | 5 | 107 | ||
a
The names of the loci are signposts and do not indicate that these loci are necessarily biologically relevant. A number of associated variants are distant from protein-coding genes.