Table 1.

Tissue expression of all 11 human organic anion transporting polypeptides (OATPs) in normal and cancer tissues

OATP	Normal tissue expression	Reference(s)	Cancer tissue expression	Reference(s)
OATP1A2	Blood-brain barrier	10,11	Expressed in bone cancer tissues and cell lines	49
	Kidney	11	Reduced in colon polyps and cancer	44
	Cholangiocytes	11
	Enterocytes	12	Increased in breast carcinoma cells and malignant breast tissue	45,46
OATP1B1	Liver	13,14,17	Reduced in hepatocellular carcinoma	50--53, 55, 56
OATP1B3	Liver	15, 18	Reduced in hepatocellular carcinoma	54
			Expressed in: Colorectal adenocarcinoma tissues	58
			Non-small-cell lung tumors	50
			Prostate cancer tissue	60,61
			Invasive ductal carcinoma breast cells	62
			Cell lines of stomach, colon, pancreatic, and gall bladder cancers	13
OATP1C1	Brain	23	Expressed in bone cancers	49
	Testes	20
	Ciliary body	24
OATP2A1	Ubiquitous	25--28	Increased in malignant breast tissue and liver cancers	47,64
			Reduced in tumors of bowel, stomach, ovary, lung, and kidney	63
OATP2B1	Liver	29a	Increased in bone cysts	49
	Blood-brain barrier	31	Altered in breast cancers	47,65
	Enterocytes	30
	Placenta	34
	Heart	32
OATP3A1	Ubiquitous	35--37	Expressed in bone cancer and	49
			Cancer cell lines of multiple tissues	29, 33, 37, 66, 67
OATP4A1	Ubiquitous	29, 39, 40	Expressed in bone cancer and	49
			Cancer cell lines of multiple tissues	29, 33, 47, 66
OATP4C1	Kidney	41
OATP5A1	Lactiferous ducts in breast	37	Expressed in malignant breast tumors	37
OATP6A1	Testes	42,43	Expressed in tumors of the lung, bladder, and esophagus	42