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Assessment of global translation initiation by changes in 4e-BP-1 activation in liver (A), heart (B), and skeletal muscle (C). There was a significant increased phosphorylation in liver with CR, which indicates decreased translation initiation. Skeletal muscle appears to have variable results since total 4e-BP decreases with CR and age, but not phosphorylation. In heart phopshorylation decreased with age. *Significant difference between AL and CR, p ≤ 0.05. n = 5 per group.
