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. Author manuscript; available in PMC: 2013 Jan 11.
Published in final edited form as: J Am Chem Soc. 2011 Dec 14;134(1):256–262. doi: 10.1021/ja206455t

Figure 3.

Figure 3

a) Crystal structure of the HHRz27 (pdb: 2OEU) with modeled Pt(II) reagent. b) Structural model of Pt(NH3)2(OH2) bound to the Rp stereoisomer of a C1.1 phosphorothioate. Distances from Pt(II) to G8, the major site of PtII crosslinking, and additional site G10.1 are indicated. Distances to other purine N7 sites and model built with the Sp stereoisomer are given in Figure S2. Models generated as described in Methods.