. Author manuscript; available in PMC: 2013 Jan 11.

Published in final edited form as: J Am Chem Soc. 2011 Dec 14;134(1):256–262. doi: 10.1021/ja206455t

Table 1.

Pt(II)-phosphorothioate RNA crosslinking rate constants and yields. Conditions: 40 μM RNA in 1mM Mg(NO₃)₂, 100 mM NaNO₃, 10 mM Na₂PO₄, pH 7.0, 120 μM [Pt(NH₃)₂(OH₂)Cl]⁺, 37°C.

[Mg²⁺]	Fast k_obs (min⁻¹)	Fast k_{2, calc} (M⁻¹s⁻¹)	Slow k_obs (min⁻¹)	Slow k_{2, calc} (M⁻¹s⁻¹)	Average Yield
0.1 mM	0.55 ± 0.19	76 ± 26	0.02 ± 0.02	3 ± 2	13%
1 mM	0.34 ± 0.04	47 ± 5	0.01 ± 0.01	1 ± 1	20%
10 mM	0.14 ± 0.01	19 ± 1	0.01 ± 0.01	1 ± 1	30%