. Author manuscript; available in PMC: 2013 Jan 12.

Published in final edited form as: J Med Chem. 2011 Dec 30;55(1):357–366. doi: 10.1021/jm201231w

Table 1.

CPP-115alone is not rewarding and blocks the expression of preference to cocaine. CPP-115 (1 mg/kg) and vigabatrin (300 mg/kg) produced comparable inhibition of cocaineinduced place preference, p<0.001, Student’s t-test

Treatment Group	number of animals	Time in chamber (min)
Treatment Group	number of animals	paired	unpaired
Saline/Saline^a	9	7.3 ± 0.5	7.7 ± 0.6
Saline/Cocaine^a	9	11.8 ± 0.4	3.2 ± 0.4
Saline/CPP-115	8	8.1 ± 0.2	6.9 ± 0.9
CPP-115/Cocaine	8	7.8 ± 0.5	7.2 ± 0.9
Vigabatrin/Cocaine^a	10	7.9 ± 0.5	7.1 ± 0.6

Dewey et al.⁷