Figure 4.

Inhibition of esophageal cancer cell growth by curcumin, (-)-epigallocatechin-3-gallate, lovastatin and their combinations in nude mouse xenografts. Esophageal adenocarcinoma SKGT-4 cells were inoculated subcutaneously into nude mice (5 per group). Two days before tumor cell injection, the mice started treatment with or without curcumin (Cur) (50 μg/kg per day), (-)-epigallocatechin-3-gallate (EGCG) (50 μg/kg per day), lovastatin (Lov) (50 μg/kg per day) and their combinations (the same doses as given individually) for 30 d (5 d/wk by oral gavage). At the end of the experiments, the xenograft tumor mass was isolated and weighed and summarized.