Skip to main content
. 2011 Dec;13(12):1101–1112. doi: 10.1593/neo.111060

Figure 1.

Figure 1

Wnt signaling is elevated in human schwannoma cells. (A) Western blot analyses were carried out to compare the levels of β-catenin between Schwann and schwannoma cells. RhoGDI was used as a loading control between Schwann and schwannoma cells. No significant difference (ns) was observed after quantification and statistical analysis (n = 5). Error bars represent the mean ± SEM. (B) β-Catenin localizes in the nucleus of schwannoma but not Schwann cells. Confluent and 24-hour starved human Schwann (NF2+/+) and schwannoma cells (NF2-/-) were immunostained with DAPI (nuclear marker) and β-catenin. Scale bar, 20 µm. (C) ABC and Wnt target genes are elevated in schwannoma. Western blot analyses were carried out to compare the level of ABC, c-myc, and cyclin D1. (D) The nuclear portion of β-catenin in schwannoma is ABC. Immunostaining was carried out for ABC, DAPI, and cytoskeleton marker F-actin in Schwann and schwannoma cells. Scale bar, 10 µm.