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. Author manuscript; available in PMC: 2012 Jan 13.
Published in final edited form as: Cell Metab. 2011 Jun 8;13(6):655–667. doi: 10.1016/j.cmet.2011.03.023

Figure 3. Autophagy Is Induced in Response to Lipid Loading, and LAL Mediates LD Catabolism.

Figure 3

(A) Chloroquine inhibits cholesterol efflux in macrophage foam cells, but not in unloaded cells.

(B) Chloroquine has no effect on cholesterol efflux at an early time point, but impairs cholesterol efflux upon prolonged inhibition of lysosomal function.

(C) Autophagic flux is induced in lipid-loaded macrophages.

(D and E) Effect of LAL inhibition on cholesterol efflux (D) and cellular CE mass (E) in unloaded versus lipid-loaded macrophages.