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. 2011 Nov 14;195(4):543–552. doi: 10.1083/jcb.201103106

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© 2011 Maiden and Hardin

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — The role of α-catenin in cell–cell adhesion. (A) The cadherin–catenin complex (CCC). The transmembrane cadherin mediates cell–cell adhesion through calcium-dependent homophilic binding of an adjacent cadherin. Intracellularly, cadherin interacts directly with p120-catenin and β-catenin. α-Catenin joins the complex by binding to β-catenin through its N terminus, while the C-terminal actin-binding domain recruits the actin cytoskeleton. (B) Key features of α-catenin, including the three vinculin homology (VH) domains and the binding sites of several proteins discussed in this review.