Table 3. Analysis of outcome measures (change from baseline).
| Outcome |
AT |
TAU |
Unadjusted |
Adjusted |
||||
|---|---|---|---|---|---|---|---|---|
| N | Mean (s.d.) | N | Mean (s.d.) | Mean difference (95% CI) | P-value | Mean difference (95% CI) | P-value | |
| SBP | 68 | −22.1 (9.7) | 68 | 1.0 (5.5) | −23.1 (−25.9, −20.4) | <0.01 | −21.6 (−24.4, −18.8) | <0.01 |
| DBP | 68 | −14.7 (8.6) | 68 | 0.5 (3.9) | −15.2 (−17.6, -12.8) | <0.01 | −12.8 (−15.0, −10.6) | <0.01 |
| G-H | 68 | −5.8 (2.4%) | 68 | −0.1 (1.1) | −5.67 (−6.3, −5.0) | <0.01 | −5.0 (−5.6, −4.4) | <0.01 |
| G-O | 68 | −1.2 (1.9) | 68 | 0.1 (1.3) | −1.3 (−1.9, −0.8) | <0.01 | −1.4 (−2.1, −0.8) | <0.01 |
| G-S | 68 | −1.8 (1.6) | 68 | 0.02 (1.32) | −1.8 (−2.3, −1.3) | <0.01 | −1.9 (−2.4, −1.4) | <0.01 |
| G-B | 68 | 2.6 (2.4) | 68 | 0.37 (1.59) | 2.3 (1.5, 3.0) | <0.01 | 1.8 (1.2, 2.5) | <0.01 |
| Percentage adherence at 11 weeks | 68 | 97.2% (4.0) | 68 | 70.6% (10.7) | 26.7% (23.9, 29.4) | <0.01 | 26.4% (23.4, 29.4) | <0.01 |
| Medication changes over 11 weeks | 68 | 8.2 (12.1%) | 68 | 16.8 (24.7%) | OR (95% CI) 0.4 (0.2, 0.6) | 0.08 | OR (95% CI) 0.6 (0.2, 1.7) | 0.30 |
Abbreviations: AT, adherence therapy; DBP, diastolic blood pressure; G-H, general harm; G-O, general overuse; G-S, general sensitivity; G-B, general benefit; OR, odds ratio; SBP, systolic blood pressure; TAU, treatment as usual.
Unadjusted analysis based on a two-sample t-test and adjusted analysis based on an analysis of covariance model.