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. 2011 Nov 28;195(5):903–920. doi: 10.1083/jcb.201103045

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© 2011 Magalhaes et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — A model for how cortactin phosphorylation regulates invadopodium maturation and tumor cell invasion through a pH-dependent pathway. Cortactin tyrosine phosphorylation regulates the interaction between NHE1 and cortactin. NHE1 alkalinizes the local invadopodia pH and induces the release of cortactin-bound cofilin. Released cofilin activates barbed end generation at the invadopodia and is deactivated by either phosphorylation or by rebinding cortactin after a decrease in local pH.