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. 2011 Nov 28;195(5):889–902. doi: 10.1083/jcb.201104040

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© 2011 Karotki et al.

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Figure 8. — Model for the assembly of eisosomes on the plasma membrane. (A) The assembly of eisosomes can be separated conceptually into three steps: interactions of the proteins to form dimers (interaction 1), association of dimers to form thin filaments (interaction 2), and assembly into helices (interaction 3). Rings observed for Pil1 are interpreted in this model as side products of the filament-to-helix assembly. (B) On the plasma membrane (PM), main eisosome components assemble into a scaffold similar to a half helix (see Discussion for details).